Comparative Characteristics of The 1st Biochemical Screening Results in Pregnant Females With Thrombophilic Polymorphisms

Article Information

E.S. Korosteleva, O.Iu. Ivanova*

Kursk State Medical University, 3, Karla Marksa Street, Kursk, 305041, Russia

*Corresponding Author: O.Iu. Ivanova, Kursk State Medical University, 3, Karla Marksa Street, Kursk, 305041, Russia

Received: 19 March 2018; Accepted: 26 March 2018; Published: 28 March 2018

Citation:

E.S. Korosteleva, O.Iu. Ivanova. Comparative Characteristics of The 1st Biochemical Screening Results in Pregnant Females With Thrombophilic Polymorphisms. Obstetrics and Gynecology Research 1 (2018): 019-020.

Share at Facebook

Keywords

Thrombophilic Polymorphisms

Thrombophilic Polymorphisms articles Thrombophilic Polymorphisms Research articles Thrombophilic Polymorphisms review articles Thrombophilic Polymorphisms PubMed articles Thrombophilic Polymorphisms PubMed Central articles Thrombophilic Polymorphisms 2023 articles Thrombophilic Polymorphisms 2024 articles Thrombophilic Polymorphisms Scopus articles Thrombophilic Polymorphisms impact factor journals Thrombophilic Polymorphisms Scopus journals Thrombophilic Polymorphisms PubMed journals Thrombophilic Polymorphisms medical journals Thrombophilic Polymorphisms free journals Thrombophilic Polymorphisms best journals Thrombophilic Polymorphisms top journals Thrombophilic Polymorphisms free medical journals Thrombophilic Polymorphisms famous journals Thrombophilic Polymorphisms Google Scholar indexed journals trophoblast articles trophoblast Research articles trophoblast review articles trophoblast PubMed articles trophoblast PubMed Central articles trophoblast 2023 articles trophoblast 2024 articles trophoblast Scopus articles trophoblast impact factor journals trophoblast Scopus journals trophoblast PubMed journals trophoblast medical journals trophoblast free journals trophoblast best journals trophoblast top journals trophoblast free medical journals trophoblast famous journals trophoblast Google Scholar indexed journals pregnancy articles pregnancy Research articles pregnancy review articles pregnancy PubMed articles pregnancy PubMed Central articles pregnancy 2023 articles pregnancy 2024 articles pregnancy Scopus articles pregnancy impact factor journals pregnancy Scopus journals pregnancy PubMed journals pregnancy medical journals pregnancy free journals pregnancy best journals pregnancy top journals pregnancy free medical journals pregnancy famous journals pregnancy Google Scholar indexed journals reproductive articles reproductive Research articles reproductive review articles reproductive PubMed articles reproductive PubMed Central articles reproductive 2023 articles reproductive 2024 articles reproductive Scopus articles reproductive impact factor journals reproductive Scopus journals reproductive PubMed journals reproductive medical journals reproductive free journals reproductive best journals reproductive top journals reproductive free medical journals reproductive famous journals reproductive Google Scholar indexed journals biochemical articles biochemical Research articles biochemical review articles biochemical PubMed articles biochemical PubMed Central articles biochemical 2023 articles biochemical 2024 articles biochemical Scopus articles biochemical impact factor journals biochemical Scopus journals biochemical PubMed journals biochemical medical journals biochemical free journals biochemical best journals biochemical top journals biochemical free medical journals biochemical famous journals biochemical Google Scholar indexed journals pregnant women articles pregnant women Research articles pregnant women review articles pregnant women PubMed articles pregnant women PubMed Central articles pregnant women 2023 articles pregnant women 2024 articles pregnant women Scopus articles pregnant women impact factor journals pregnant women Scopus journals pregnant women PubMed journals pregnant women medical journals pregnant women free journals pregnant women best journals pregnant women top journals pregnant women free medical journals pregnant women famous journals pregnant women Google Scholar indexed journals inflammatory diseases articles inflammatory diseases Research articles inflammatory diseases review articles inflammatory diseases PubMed articles inflammatory diseases PubMed Central articles inflammatory diseases 2023 articles inflammatory diseases 2024 articles inflammatory diseases Scopus articles inflammatory diseases impact factor journals inflammatory diseases Scopus journals inflammatory diseases PubMed journals inflammatory diseases medical journals inflammatory diseases free journals inflammatory diseases best journals inflammatory diseases top journals inflammatory diseases free medical journals inflammatory diseases famous journals inflammatory diseases Google Scholar indexed journals urinary tract articles urinary tract Research articles urinary tract review articles urinary tract PubMed articles urinary tract PubMed Central articles urinary tract 2023 articles urinary tract 2024 articles urinary tract Scopus articles urinary tract impact factor journals urinary tract Scopus journals urinary tract PubMed journals urinary tract medical journals urinary tract free journals urinary tract best journals urinary tract top journals urinary tract free medical journals urinary tract famous journals urinary tract Google Scholar indexed journals chorionic gonadotrophin articles chorionic gonadotrophin Research articles chorionic gonadotrophin review articles chorionic gonadotrophin PubMed articles chorionic gonadotrophin PubMed Central articles chorionic gonadotrophin 2023 articles chorionic gonadotrophin 2024 articles chorionic gonadotrophin Scopus articles chorionic gonadotrophin impact factor journals chorionic gonadotrophin Scopus journals chorionic gonadotrophin PubMed journals chorionic gonadotrophin medical journals chorionic gonadotrophin free journals chorionic gonadotrophin best journals chorionic gonadotrophin top journals chorionic gonadotrophin free medical journals chorionic gonadotrophin famous journals chorionic gonadotrophin Google Scholar indexed journals infants articles infants Research articles infants review articles infants PubMed articles infants PubMed Central articles infants 2023 articles infants 2024 articles infants Scopus articles infants impact factor journals infants Scopus journals infants PubMed journals infants medical journals infants free journals infants best journals infants top journals infants free medical journals infants famous journals infants Google Scholar indexed journals

Article Details

Thrombophilic polymorphisms are ethiopathological triggers of reproductive losses and pregnancy complications [1]. Implantation, trophoblast invasion and further placental functioning are objectively impaired in the presence of genetic coagulation defects [2,3].

The purpose of our research was to study the trophoblast function in early pregnancy in females of the Kursk region with genetic trombophilic polymorphisms.

115 female patients were included into the retrospective study. The main group consisted of 78 patients with reproductive losses after 12 gestation weeks against the background of genetic trombophilic polymorphisms. The control group was comprised of 37 patients with uncomplicated pregnancy and delivery, without trombophilic polymorphisms, who gave birth to healthy full-term infants.

The following parameters were analyzed: clinical history of patients, levels of β-subunit of human chorionic gonadotrophin (β-hCG) and pregnancy-associated plasma protein A ( PAPP-A) during the 1st screening.

The mean patient age in the main group was 31.5±3.7 years. The females in the main and control groups were comparable by age (p>0.05). Among extragenital diseases, cardiovascular diseases (94.8% (74)) were predominant in the main group; varicose vein disease of lower extremities was detected in 52.6% (41) patients, lipid metabolism disorders in 48.7% (38) cases, as well as inflammatory diseases of the urinary tract (in remission during pregnancy) were diagnosed (48.7% (38)). The number of females with extragenital diseases in the control group was significantly lower compared to the main one (p<0.01).

Obstetric history analysis revealed that the overwhelming majority of the main group females were multigravida (65.4% - 51), 15.4% (12) patients were multipara. The control group mainly consisted of primigravida and primipara females (75.7% - 28).

10.3% (8) females were diagnosed with an isolated MTHFR: 677C/T defect. Polygenic mutations were detected in 89.7% (70) patients. The combination of two mutations was found in 48.6% (34) pregnant women, three mutations - in 27.1% (19), four mutations in 18.6% (13), and five mutations in 5.7% (4). The most common combination of genetic trombophilic polymorphisms in case of two mutations was MTHFR: 677C/T and PAI-1: 675 5G/4G. For three mutations it was the genetic polymorphism MTHFR: 677C/T, MTRR:A66G, and MTR:A2756G; for four mutations, that was MTHFR:677C/T, MTRR:A66G, MTR:A2756G, and PAI-1: 675 5G/4G.

The analysis of biochemical screening results in the main group revealed that the 1-1.5 MoM range (1.306 ± 189 MoM) for β-hCG included data for 43.6% (34) patients; in 56.4% (44) females, β-hCG level was < 1 (0.653 ± 167 MoM). PAPP-A parameters showed that the 1-1,5 MoM range comprised the parameters for 37.2% (29) patients (1.418 ± 87 MoM), in 42.3% (33) patients PAPP-A level was < 1 (0.762 ± 204 MoM), while in 20.5% (16) it was >

MoM (1.589 ± 84 MoM). For control group females, β-hCG and PAPP-A parameters were within 1-1.5 MoM (1.322 ± 105 MoM).

It was demonstrated that the overwhelming majority of pregnant women with thrombophilic polymorphisms had a decreased hormonal trophoblast function, which was reflected by β-hCG and PAPP-A parameters during the 1st biochemical screening (p<0.05).

References

  1. M.V. Khruslov, O.Iu. Ivanova, M.I. Boeva, E.S. Kosinova. Detection of conditions with possible positive pregnancy outcomes in females with hereditary thrombophilias. Thrombosis, hemostasis, and reology 67S3 (2016) 441-442.
  2. E.V. Alegina, N.K. Tetruashvili, A.A. Agadzhanova et al. Genetic polymorphism as a factor predisposing to habitual pregnancy losses. Obstetrics and gynecology 4 (2014): 25-31.
  3. A.D. Makatsaria, F.A. Chervenak, V.O. Bitsadze. High-risk pregnancy. Medical Information Agency JSC 2015: 920.

© 2016-2024, Copyrights Fortune Journals. All Rights Reserved