Serum Enzymes in Myocardial Infarction Patients: A Study of Survival Time After Recovering

Author(s): Huynh Dinh Chien, Jing Nie, Duong Thi Bich Thuan, Megan Aikawa, Dang Ngoc Khoi, Joan Dorn, Jo Freudenheim, Maurizio Trevisan

This study investigates the long-term prognostic role of serum enzyme levels in survivors of myocardial infarction (MI). We evaluated a cohort of 1496 individuals (1064 males and 432 females) aged 35-69 years, following them for a period of 14-22 years. The study aimed to elucidate the association between serum concentrations of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) and mortality outcomes, including all-cause mortality, cardiovascular disease (CVD), and coronary heart disease (CHD). Results revealed a statistically significant inverse association between LDH levels and mortality from all causes, CVD, and CHD. Conversely, ALT exhibited positive correlations with both CVD and all-cause mortality, and AST showed a positive association with all-cause mortality. Notably, GGT and ALP did not demonstrate any significant associations with any of the investigated mortality endpoints. Importantly, these observed relationships between serum enzyme levels and mortality outcomes remained statistically independent after adjusting for potential confounding variables such as age, sex, blood pressure, serum glucose and cholesterol levels, body mass index (BMI), smoking status, and alcohol consumption.