Real-time Tissue Properties from “Intelligent iSyringe” Pressure Transient Analysis

Author(s): Jamie A. Chin

A new imaging approach offering real-time quantitative local tissue information, complementing conventional X-ray, ultrasound, Catscan and MRI techniques that produce qualitative, global, subjective grayscale descriptions is described. Its importance in medical clinical tissue characterization is underscored. Applications to manufactured (or cultivated) meat manufacturing, agricultural products, and pastry product formulation are also introduced. In short, pressure transients obtained and recorded during syringe injections and withdrawals can be interrogated using physics-based mathematical models using rapid real-time algorithms for permeability, anisotropy, compressibility, porosity and pore pressure. The general math boundary value problem, together with explicit solutions, is offered and applied to available datasets for swine and human subjects, plus newly acquired pressure transient data suites for uncooked meats, fruits, vegetables and pastry products. Also described in our exploratory investigations is a new software and hardware prototype system, consisting of a pressure transducer instrumented syringe, interpretation algorithms, auto-injector for flow rate control, wireless data acquisition and computer, together with suggested workflows for convenient, inexpensive, rapid porous media monitoring in routine tests, periodic monitoring and multiple syringe applications.