Real World Experience with Osteosarcoma from a Tertiary Cancer Centre in India

Author(s): Pankaj Goyal, Srujana Joga, Rupal Tripathi, Arpit Jain, Manish Sharma, Varun Goel, Vineet Talwar, Ullas Batra, Sunil Pasricha, Dinesh Chandra Doval

Background: Osteosarcoma represents the commonest category of bone tumors in the children and young adults and stability in its incidence rates have been observed throughout the world. The present study evaluated the varied profile of Indian patients with osteosarcoma with a special emphasis on the survival patterns in a tertiary cancer care centre in India.

Methods: A retrospective review of all patients diagnosed with osteosarcoma during the year 2000 to 2020 was included in the study. Details of their demographic, treatment and survival profile were collected from the electronic medical records of the patients.

Results: Among 112 patients, male gender (75.9%), disease in extremity sites (89.3%), conventional histology (95.5%), serum alphos >120U/L (75.9%) and non-metastatic disease at presentation (66.1%) and IAP regime (57.1%) were more commonly reported. The OS of the patients was 51% at 20 years. Statistical associations were observed with respect to age (p-value 0.019), site (p-value 0.017), grade (p-value 0.019), metastatic disease (p-value 0.006) and site of metastasis (p-value <0.0001). The PFS of the patients was 48% at 20 years and correlations were observed with respect to age (p-value 0.021), site (p-value 0.002), grade (p-value 0.016), metastatic disease (p-value 0.001), site of metastasis (p-value <0.0001) and HUVOS grade (p-value 0.026).

Conclusion: With a static pattern in survival, there is an imperative need to characterize the genetic, epigenetic and immunologic basis of the disease in order to look for newer targets, inhibitors and therapies.