Penile Paget ’s Disease: A Case Report and Review of the Literature

Author(s): Flanigan RC, Dornbier R, Quek ML, Woods M, Gorbonos A, Gupta G, Harkenrider MM, Solanki A, Badami A, Henry E, Berg S, Bova D, Barkan GA, Picken MM

Extramammary Paget’s Disease (EMPD) is a rare cutaneous, slow growing, intraepithelial adenocarcinoma that can be either primary (intraepithelial arising within the epidermis) or secondary (intraepithelial spread of a visceral carcinoma). Here we present the case of a 63-year-old male with EMPD of the glans penis stemming from underlying urothelial carcinoma. Our treatment decision elected for management with chemotherapy and local treatment with radiation therapy. Subsequent, review of the literature demonstrated a rare disease with a variety of underlying malignancies causing this secondary pathology. Caregivers should be aware of the association of Paget’s disease and urothelial cancer and should have a high index of suspicion that erythematous penile lesions may represent Paget’s disease and that penile biopsies should be performed early in this setting.


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