Newly Described Eosinophilic, Solid and Cystic Renal Cell Carcinoma: A Case Report and Review of the Literature

Author(s): Aaron Yunker, Luke Holder, Joshua Nething

Introduction: Renal cell carcinoma accounts for 2-3% of adult malignant neoplasms and has the worst prognosis of the common urologic malignancies. According to the 2016 WHO classification there are 16 distinct histologic subtypes for renal cell carcinoma. Recently, an eosinophilic, solid and cystic renal cell carcinoma histologic subtype has been described and proposed as a separate entity. There are only 60 cases reported in the literature, here we report the 61st case and review the literature.

Case Report: A 59-year-old woman presented in December 2018 with a renal mass found incidentally on a screening Computed Tomography. Magnetic Resonance Imaging of the Abdomen with and without contrast revealed an enhancing 2cm right lower pole renal mass. The patient elected to undergo laparoscopic with robotic assistance right retroperitoneal partial nephrectomy in March of 2019. Pathology was consistent with eosinophilic, solid and cystic renal cell carcinoma.

Discussion: ESC RCC is an emerging entity whose incidence will continue to rise as it is better recognized. To our knowledge, this is the 61st reported case. After reviewing the literature, we compiled a table comparing the available data for each of the 61 cases. We found that It predominantly affects females at a younger age than other forms of RCC. It appears to be more indolent than clear cell RCC with higher rates of organ-confined disease and lower rates of stage IV disease. There is limited data regarding imaging findings and only one article that looked at this specifically. There were only 3 cases of metastasis.