Health-Related Quality of Life and Associations on Socio-Demographic and Clinical Factors in Schizophrenia Based on the QLICD-SC Scale: A CrossSectional Study

Author(s): Shuying Rao, Dandan Wang, Junding Xian, Zhixiong Lin, Wanrui MA, Benli Xue, Yuxi Liu, Chonghua Wan

Background: Literature on factors that influence schizophrenia patients’ quality of life is confined to socio-demographic elements and clinical factors have not been verified. The current study aimed to examine the health-related quality of life and its associated factors of schizophrenics by using the scale Quality of Life Instruments for Chronic Diseases-Schizophrenia (V2.0)(QLICD-SC)), which is modular and sensitive.

Methods: 163 people who met the diagnostic criteria for schizophrenia of the International Classification of Diseases(10th Revision) and were hospitalized at the Affiliated Hospital of Guangdong Medical University from May 2014 to December 2015 were recruited. Patients' clinical objective indexes, including blood routine, urine routine, blood biochemical examination, blood gas analysis were collected by reviewing the medical records. Patients were administered the QLICD-SC (V2.0), a quality of life measurement scale for schizophrenia. Simple correlation analysis was used to explore the correlation between the QLICD-SC (V2.0) scores and various clinical objective indicators, and multiple linear regression was used to further screen for correlates.

Results: There were 163 participants, ranging in age from 16 to 69, with a 30.67±11.44 average age. The majority of them were men(57.1%), had a high school diploma (77.9%), and were married (65.6%). According to multiple linear regression, the variables of physical function included in the model were serum phosphorus and urine white blood cell (B=-28.628, -33.797, P<0.01). The variables included in the model of social function were education and nitrituria (B=5.708, -18.563, P<0.05). The variables included in the model of special module were gender and hematocrit (B=38.184, 4.147, P<0.05). No variable was included in psychological function and total scale score.

Conclusion: Some clinical indicators such as serum phosphorus, urine white blood cell, nitrituria, and hematocrit as well as socio-demographic factors including education and gender may affect the quality of life for schizophrenic people

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