Gestational Diabetes Mellitus: Safety and Efficacy of Regular Insulin and Metformin During Pregnancy

Author(s): Jais kumar, Kishore kumar

Gestational diabetes mellitus is a common metabolic disorder diagnosed during pregnancy. During pregnancy insulin resistance increases due to placental, growth and progesterone hormones. As pregnancy precedes the insulin resistance increase gradually, making hyperglycemia worse. The main task is to control hyperglycemia during pregnancy to prevent maternal and fetal complications. Initially diet and physical exercise is encouraged otherwise drug management is required. Combination of regular insulin and Metformin is an effective way to control hyperglycemia in gestational diabetes mellitus when diet and moderate exercise alone is ineffective.

Period: July 2016 to December 2016.

Objectives: The objective of this study was to determine the safety and efficacy of regular insulin and Metformin in gestational diabetes mellitus.

Study Design: A prospective descriptive study.

Place of Study: Pakistan Institute Of Medical Sciences Islamabad

Results: Among one hundred and forty seven (147) gestational diabetic women, we found that combination of regular insulin and Metformin is safe and effective to control hyperglycemia in gestational diabetes mellitus.

Conclusion: Combination of regular insulin and Metformin is an effective way to control hyperglycemia in gestational diabetes mellitus when diet and moderate exercise alone is ineffective.