Emergence of a Pathogenic Strain of COVID-19

Author(s): Shreyans Chatterjee, Tathagata Dey, Smarajit Manna

SARS-CoV-2 pandemic starting from Wuhan, China has now been spreading worldwide making the infection count more than 41 million. Within a short time span, many mutations are continuously occurring in the viral genome, be it point mutation or frameshift mutation. Scientists have been suggesting that, one of those numerous point mutations is becoming prevalent by replacing all the initial Wuhan strains of SARS-CoV-2. In this work, we have conducted a rigorous bio-informatic analyses and compared the properties of wild and mutant strains to find out the changes. Eventually, it is considered to be a more pathogenic and infective strain by our theoretical reports with a change in amino acid position number 614, which coincidentally converges with one or few publications mentioning emergence of new pathogenic D614G strain. Here we describe our approach to arrive at the conclusion.

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