Association of Highly Sensitive C-Reactive Protein with the Severity of Preeclampsia and Fetal Outcome

Author(s): Aktar MN, Smriti M, Rahman M, Haque KS, Islam M, Kundu PR, Islam N, Sharmin SN

Background:

Preeclampsia is one of the most common complications of pregnancy and leading cause of maternal mortality and morbidity as well as neonatal mortality and morbidity. There is exacerbated inflammation and endothelial dysfunction in preeclampsia.

Objectives:

The aim of the study was to evaluate the association between highly sensitive C-reactive protein and the severity of preeclampsia and fetal outcome in a tertiary care hospital.

Methods:

This case-control study was carried out in the Department of Obstetrics & Gynecology of Dhaka Medical College Hospital, Dhaka. A total of 60 preeclampsia patients 30 PE with severe features (cases group) and 30 PE without severe features (controls group) having gestational age between 32 to 40 weeks admitted in the Department of Obstetrics and Gynecology, fulfilled the selection criteria were enrolled in this study.

Results:

Maximum study subjects were in 21 – 30 years age group. Mean age of the study subjects was 28.13 ± 6.02 and 26.07 ± 5.44 years in PE with severe features and PE without severe features respectively. There was significant positive correlation of hsCRP with systolic BP and diastolic BP. hsCRP was found significantly higher in PE with severe features (13.90 ± 3.16 mg/L) than PE without severe features (7.59 ± 2.41 mg/L). In this study hsCRP found significantly higher in neonates with low APGAR score, IUGR, Stillbirth, LBW, Prematurity

Conclusion:

Raised highly sensitive C- reactive protein has a significant association with severity of preeclampsia and adverse fetal outcome.