Association of AgNOR and Ki-67 with Histopathological Grading in Patients Diagnosed with Gastric Carcinoma

Author(s): Thanadar Ajmiree Flora, Thanadar Tamjeeda Tapu, Rezwana Rahman Khan, Tania Gaffar.

Background:

Gastric Carcinoma is the second most prevalent cause of death worldwide, characterized by diverse histopathological grading that reflects the tumor's differentiation and aggressiveness. This study aimed to investigate the correlations between the Ki-67 labeling index, AgNOR values, and histopathological grading in gastric carcinoma patients.

Methods:

A total of sixty patients aged 35 years and older with gastric carcinoma who had received histopathological diagnoses of gastric carcinoma based on biopsies obtained through gastric endoscopy as well as resected tissue samples were included. Histopathologic grading distributions were categorized into well-differentiated, moderately differentiated, and poorly differentiated groups. Ki-67 labeling index and AgNOR values were measured, and ANOVA analysis revealed significant variations across grading. Bonferroni tests identified specific differences in means between grades. Scatter diagrams visually depict the correlation between markers and grading.

Results:

Histopathological grading distributions comprised 13.33% well-differentiated, 50% moderately differentiated, and 36.67% poorly differentiated cases. Positive correlations were observed between the Ki-67 labeling index and histopathological grading (r = 0.436, p = 0.001) and between AgNOR values and grading (r = 0.451, p = 0.001).

Conclusion:

This study highlights the significant correlations between histopathological grading, Ki-67 labeling index, and AgNOR values in gastric carcinoma. These correlations offer insights into tumor aggressiveness and cellular proliferation. These findings contribute to our understanding of gastric carcinoma's biological behavior and potential clinical implications.