A Short Commentary on Potential Role of the IFN-γ/mini-TrpRS Signaling Axis in Abdominal Aortic Aneurysm

Author(s): Corey S Moran, Ramesh B Velu, Venkat Vangaveti, Usman H Malabu, Erik Biros

Aneurysms demonstrate vascular smooth muscle cells (VSMC) phenotypic modulation characterized by the prevailing of synthetic over contractile properties. We have shown previously the ability of interferon-gamma (IFN-γ) to switch VSMC from contractile to synthetic phenotype via upregulating the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) in vitro. Here we discuss a possible role of the IFN-γ/mini-TrpRS signalling axis in the pathology of human abdominal aortic aneurysm (AAA).